GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs875971 | 1 | rs709595 | chr7:65817333 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.31 | 1.96E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs709595 | chr7:65817333 | GUSB | chr7:65425675-65447246:- | 0.28 | 5.45 | 8.07E-8 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs709595 | chr7:65817333 | RABGEF1 | chr7:66093890-66276446:+ | 0.66 | 14.35 | 4.44E-39 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs709597 | chr7:65825983 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.2 | 3.2E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs709597 | chr7:65825983 | GUSB | chr7:65425675-65447246:- | -0.25 | -4.91 | 1.23E-6 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs709597 | chr7:65825983 | LOC729156 | chr7:66274980-66309813:- | -0.16 | -3.38 | 0.00079 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs709597 | chr7:65825983 | RABGEF1 | chr7:66093890-66276446:+ | -0.65 | -13.81 | 1.01E-36 | Aortic root size |
| THCA | cis | rs2243480 | 1 | rs709607 | chr7:65449541 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -5.42 | 9.29E-8 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs709607 | chr7:65449541 | CRCP | chr7:65579805-65619551:+ | 0.29 | 4.46 | 1.01E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs709607 | chr7:65449541 | RABGEF1 | chr7:66093890-66276446:+ | -0.47 | -5.69 | 2.26E-8 | Diabetic kidney disease |
| THCA | cis | rs3781264 | 1 | rs7096678 | chr10:96069208 | TBC1D12 | chr10:96162186-96296089:+ | -0.19 | -4.21 | 3.0E-5 | Esophageal cancer and gastric cancer |
| THCA | cis | rs12780845 | 1 | rs7096692 | chr10:17180828 | TRDMT1 | chr10:17184983-17243681:- | -0.45 | -10.19 | 3.44E-22 | Homocysteine levels |
| THCA | cis | rs7097 | 1 | rs7097 | chr13:28197436 | POLR1D | chr13:28194895-28241547:+ | 0.17 | 4.06 | 5.67E-5 | Large B-cell lymphoma |
| THCA | cis | rs6585827 | 1 | rs7097701 | chr10:124171857 | PLEKHA1 | chr10:124134220-124191866:+ | -0.21 | -5.75 | 1.61E-8 | Height |
| THCA | cis | rs4409766 | 1 | rs7098825 | chr10:104628234 | AS3MT | chr10:104613967-104661653:+ | -0.28 | -3.76 | 0.000189 | Hypertension;Systolic blood pressure;Diastolic blood pressure |